antibacterial effects of origanum vulgare essence against multidrug-resistant acinetobacter baumannii isolated from selected hospitals of tehran, iran

results analysis of the essential oil revealed the presence of pulegone (68.59%) piperitone (7.8%), piperitenone (7.8%), 1, 8-cineole (1.3%), and carvacrol (1.6%) as the major components. the results showed a significant activity against mdr a. baumannii with inhibition zones and minimal inhibitory concentration values in the ranges of 7-15 mm and 20-35 µl/ml respectively. conclusions this investigation showed that the essence oil of o. vulgare had a potent antimicrobial activity against mdr a. baumannii. further research is required to evaluate the practical values of therapeutic applications. materials and methods this oil was obtained using the hydrodistillation method and analyzed by gas chromatography mass spectrography (gc/ms). the antimicrobial activity against mdr isolates was achieved using disc diffusion method and macro-broth dilution assay. objectives the present study aimed to investigate the inhibitory effects o. vulgare essence against multidrug-resistant (mdr) strains of a. baumannii from selected hospitals in tehran, iran. background infection due to acinetobacter baumannii has become a significant challenge to modern healthcare systems. the rapid emergence and global dissemination of a. baumannii as a major nosocomial pathogen is remarkable and it demonstrates its successful adaptation to the 21st century hospital environment. recent studies have discussed about essential oil of origanum vulgare against a range of bacteria, including various species of staphylococcus, pseudomonas, bacillus and escherichia coli.